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KMID : 0388120050140010016
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Journal of Korean Society for the Study of Obesity
2005 Volume.14 No. 1 p.16 ~ p.21
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Changes of Lipogenic and Lipolytic Activities Following Repeated Fasting and Refeeding in Rat
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Lee Chang-Koo
Kim Yong-Woon
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Abstract
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Background: It is known that repeated fasting and refeeding increase capacity of fat storage in adipose tissue
as an adaptive response to fasting. However, the amount of weight gain in fasted/refed animals falls behind the control level in most rodent studies. Because body weight is regulated by the balance between fat storing effect and fat losing mechanism, it is postulated that there is a certain protective mechanism working against body weight gain following repeated cycles of fasting and refeeding.
Methods: In this study, the adaptive responses to repeated cycles of one-day fasting and one-day refeeding
for 42 days (RFR) were investigated in rats.
Results: The RFR rats gained less body weight than controls. LPL mRNA level of RFR rats was significantly
increased in white adipose tissue compared to controls. However, mRNA levels of leptin and adiponectin in these rats were also significantly increased in white adipose tissue compared with controls. Moreover, UCP1 expression in the brown adipose tissue was also increased in RFR rats compared to controls.
Conclusion: These data indicated that RFR decreased body weight and fat mass despite increased expression of LPL, which resulted from increased expression of leptin, adiponectin, and UCP1 in RFR rats.
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KEYWORD
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Repeated fasting, Leptin, Adiponectin
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